Pathology EMQ template.

Name: Susan Tadros

Candidate number:

Theme: Stem cell transplantation

OPTION LIST

A	Acute Graft vs. Host disease	I	Graft vs. leukaemia
B	Candidiasis	J	G-CSF
C	CMV infection	K	GM-CSF
D	CXCR- 4 antagonist	L	Invasive aspergillosis
E	Chronic Graft vs. Host disease	M	VZV infection
F	Disease relapse	N
G	E.coli infection	O
H	Graft failure	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 60 year old man with Hodgkins lymphoma is due to have an autologous SCT. In order to mobilise stem cells from his bone marrow which cytokine is most commonly used?

2. A 7 year old boy with aplastic anaemia is given a SCT from his HLA-identical brother. One month after the transplant the patient develops a bright red rash on his palms and soles. His mother tells you he has watery diarrhoea. What is the likely diagnosis?

3. A patient presents one month after a SCT with fever, shortness of breath and pleuritic chest pain. What is the likely diagnosis?

4. Following SCT in a patient with Acute lymphocytic leukaemia, all three cell lineages in both the blood and marrow are absent. What is the likely reason?

5. Two months following a SCT a 45 year old patient presents with dry mouth and eyes, shortness of breath and joint pain. His Hb is 9g/dl and a platelet count of 90x10⁹/L. What is the likely diagnosis?

ANSWERS

1. J

2. A

3. L

4. H

5. E